- Most advanced and complete nutritional regimen for maintaining strong, healthy bones*
- Promotes Bone Density
- Published clinical trial
- Complete multinutrient bone-health system
From the manufacturer
Nutrients to Support Bone Density*
Bone-Up is the most advanced and complete nutritional regimen for maintaining strong, healthy bones.* Bone-Up utilizes the finest source of calcium available: microcrystalline hydroxyapatite. While calcium is important for bone mineral density (BMD), the bone matrix also requires nutrients like vitamin C, silicon, and vitamin K. Vitamin D is also essential for absorbing more calcium.
Who Needs to Supplement Calcium?
2%-4% of your skeleton is “remodeled” every year as bone cells are broken down as we age. As a result, calcium and other minerals in the rest of the bone matrix must be replaced. Poor nutrition or the onset of aging can result in a loss of calcium and other minerals from the bone, creating tiny holes that make bones weak and brittle. Proper diet, exercise, and supplements can help.
Clinically Documented Formula
In an 8-week double-blind placebo-controlled study, supplementation with Bone-Up (not placebo) was found to produce statistically significant decreases in bone degradation markers, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OH- vitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.*
(Disilvestro RA et al. J Nutr Environ Med. 2007; 16(1):26-32)
Jarrow Formulas was founded in 1977 and operates its own GMP-certified manufacturing facility in Southern California.
The Jarrow Advantage
Our mission from the beginning has been to promote optimal health with high-quality, effective, affordable, and superior formulation of dietary supplements.
Jarrow Formulas’ staff of scientists and health professionals are actively involved in clinical studies and continually work with researchers from universities and institutes around the world. Jarrow Formulas strives to formulate products that help empower individuals to take charge of their own health.
Jarrow Formulas’ customers can be assured of purity and potency when choosing from our complete line of supplements, probiotics, herbal extracts, and condition-specific formulations.
Size:120 Count (Pack of 1)
Bone-Up provides StimuCal ossein MicroCrystalline HydroxyApatite (MCHA) (from free-range New Zealand calves), which includes the superior combination of the inorganic calcium lattice of MCHA within an organic protein milieu. StimuCal is rich in native type I collagen—the predominant protein found in bone—and has been clinically demonstrated not to disproportionately spike calcium blood levels as do other forms of calcium, such as the carbonate and citrate salt forms.* StimuCal is combined with vitamin D3 and vitamin K2 (as MK-7 from natural fermentation [a more bioavailable form of vitamin K]) to support the proper deposition of calcium into the bone matrix, thereby maintaining skeletal integrity, as well as supporting cardiovascular and arterial health.* Potassium citrate is a systemic alkalizer added for optimal osteo support.* HEALTH CLAIM: Adequate calcium and vitamin D as part of a healthful diet, along with physical activity, may reduce the risk of osteoporosis later in life. For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon
Jarrow Formulas Bone-Up provides comprehensive supplemental nutritional support for maintaining strong, healthy bones.* Bone-Up has been a featured product of Jarrow Formulas for some time and has been updated through the years to reflect the latest scientific findings regarding skeletal health.
Jarrow Formulas Bone-Up, 120 Capsules
At a Glance:
- Promotes bone density*
- Provides the essentials for proper calcium utilization by the body
- Utilizes New Zealand or Australian bovine bone ossein microcrystalline hydroxyapatite (OHC)–more than just calcium
- Ideal for those who are not getting enough calcium from foods or who are on a high protein and/or high phosphorous diet
Promotes bone density with comprehensive supplemental nutrition.
Provides the essentials for proper calcium utilization by the body.View larger.
Bone Mass and Ossein Hydroxyapatite
In 1982, an important calcium supplementation study was concluded and reported by the Dept. of Medicine and Radiology, Royal Free Hospital in London, England. Fifty-three women with reduced calcium absorption and accelerated bone loss were separated into three groups and studied for over 14 months. At the conclusion of the study, only the women that received 1,000 mg of calcium from ossein hydroxyapatite (OHC) along with vitamin D showed significant support for bone-health.*
OHC produces more prolonged calcium balance than soluble calcium salts. It also allows the bone osteoblast cells to be more receptive to its components and to build bone tissue. Furthermore, OHC provides both the organic and inorganic constituents found in human bone: the hydroxyapatite microcrystals consist of calcium, phosphorous, oxygen, and hydrogen; the trace minerals zinc, strontium, silicon and iron; and proteins, amino acids and aminoglycans.*
Bone consists of calcium and phosphorous crystals embedded in a framework of interlocking protein fibers. The protein fibers are made primarily of collagen. The mineral crystals give bone hardness, strength, and rigidity. Collagen fibers impart their quality of flexibility. Hydroxyapatite composes 67 percent of the weight of bone, and the collagenous fibers make up the remaining 33 percent.*
The average adult has 1,000 – 1,200 grams of calcium in the body. Bones are the body’s largest calcium storehouse and will release calcium into the bloodstream in order to ensure correct blood levels of calcium. Thus, blood calcium levels can be normal while bone loss can be considerable.
Between 2 – 4 percent of a person’s skeleton is remodeled every year. This means that calcium and other minerals leave the bone in a process called resorption and then must be “remodeled” or replaced. Whether due to poor nutrition or reduced hormone levels with the onset of aging, the loss of calcium and other minerals from the bone creates tiny holes that make bones weak and brittle, particularly if collagen is being lost.
It has been estimated that post-menopausal women lose 0.7 percent to 2 percent of their bone per year while men lose 0.5 percent-0.7 percent. Between 45 and 75 years of age, women lose 30 percent of their skeletal structure and men lose 15 percent.
It starts with the finest source of calcium available: New Zealand or Australian bovine bone hydroxyapatite from chemical-free, range-grazed calves less than two years old (bones from veal calves are never used). Skeletal health, however, requires more than calcium. Scientific evidence conclusively demonstrates the need for other nutrients like vitamin D, vitamin K, potassium, magnesium, boron, and trace minerals such as zinc, copper, and manganese.*
Who Needs to Supplement Calcium?
Research has indicated that 85 percent of women over the age of 20 and at least 50 percent of men from age 35 consume less than the RDI for calcium. Caffeine, alcohol, sugar, high protein diets and soda (particularly sodas that are high in phosphorous) can deplete calcium.
In addition, calcium absorption has long been thought to be stomach-acid dependent, but both stomach acid production and calcium absorption decline with age.
Bone-Up Clinical Trial
The results of a clinical trial published in the Journal of Nutritional & Environmental Medicine (DiSilvestro RA et al. J Nutr Environ Med. 2007; 16(1):26-32) found that exercise and supplementation of calcium, vitamin D3 and other micronutrients from Bone-Up significantly improved bone health in young adult women.*
In an 8-week double-blind placebo-controlled study of 24 female students ages 18 to 24, supplementation with Bone-Up (not placebo) was found to produce statistically significant decreases in markers of bone degradation, while increasing levels of plasma bone specific alkaline phosphatase (an indicator of bone synthesis), plasma 2,5-OH-vitamin D (an indicator of vitamin D nutritional status) and plasma parathyroid hormone.*
Health Claim: In conjunction with regular, weight-bearing exercise and a healthy diet, calcium helps teen and young adult women build bone mass and maintain bone health, and may reduce their risk of osteoporosis later in life.* Daily calcium intake above 2,000 mg is not likely to provide additional benefit. Adequate calcium intake is also linked to reduced osteoporosis by slowing bone loss in older men and women.*
About Jarrow Formulas
Jarrow Formulas’ complete line of over 350 nutritional products includes vitamins, minerals, probiotics, standardized herbal concentrates, amino acids, enzymes and enteral nutrition products. Customers can be assured of purity, value and potency when choosing these products.
What’s in the Box
Jarrow Formulas Bone-Up, 120 Capsules.